Name: 小鼠抗SERPINB3單克隆抗體
Brand: 通蔚生物

中文名稱(chēng): 小鼠抗SERPINB3單克隆抗體

英文名稱(chēng): Anti-SERPINB3 mouse monoclonal antibody

別名: HsT1196; SCC; SCCA-1; SCCA-PD; SCCA1; T4-A

抗原: SERPINB3

儲(chǔ) 存: 冷凍（-20℃）避光

宿主: Mouse

反應(yīng)種屬: Human

相關(guān)類(lèi)別: 一抗

標(biāo) 記物: Unconjugate

克隆類(lèi)型: mouse monoclonal

技術(shù)規(guī)格

Background:	Metastasis of a primary tumor to a distant site is determined through signaling cascades that break down interactions between the cell and extracellular matrix proteins. Among the proteins mediating metastasis are serine prote-ases, such as neutrophil elastase. In 1985, Dr. Jim Travis and Dr. R.W. Carrell designated an emerging family of serine protease inhibitors as the serpin fam-ily, which share homology in both primary amino acid sequence and tertiary structure. Serpins contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. Serine proteases bind to this substrate mimic in a 1:1 stoichiometric fashion and become catalytically inactive. Aberrant ex-pression of serpin family members can contribute to a number of conditions, including emphysema (a-1 antitrypsin deficiency), fatal bleeding (elastase to thrombin specificity) and thrombosis (antithrombin deficiency), and are indicators of cancer stage phenotypes (circulating levels of squamous cell carcinoma antigen, known as SCCA1, increase in advancing stages of some cervical, lung, esophageal and head and neck cancers). Human chromosome position 18q21.3 contains a cluster of serpins, including a tandem duplication of the SCCA gene, plasminogen activator inhibitor type 2, and maspin. SCCA is transcribed by two nearly identical genes (SCCA1 and SCCA2), and is mainly produced as SCCA1. The human SCCA1 gene encodes a 390 amino acid protein that was originally isolated from a metastatic cervical squamous cell carcinoma.
Applications:	WB, IF
Name of antibody:	SERPINB3
Immunogen:	Fusion protein of human SERPINB3
Full name:	serpin peptidase inhibitor, clade B (ovalbumin), member 3 (SERPINB3)
Synonyms:	HsT1196; SCC; SCCA-1; SCCA-PD; SCCA1; T4-A
SwissProt:	P29508
WB Predicted band size:	45 kDa
WB Positive control:	COS7 cell lysate
WB Recommended dilution:	500-2000

展開(kāi)全部

小鼠抗SERPINB3單克隆抗體說(shuō)明書(shū)
下載

久久综合九九-久久综合九九亚洲一区-久久综合九色-久久综合九色欧美综合狠狠-久久综合九色婷婷97-久久综合九色综合8888

021-54845833/15800441009

ELISA試劑盒

PCR試劑盒

生化試劑盒

細(xì)胞系

細(xì)胞庫(kù)

基礎(chǔ)培養(yǎng)基

完全培養(yǎng)基

原代細(xì)胞

細(xì)胞專(zhuān)用培養(yǎng)基

菌株

生化試劑

病理染色液

科研抗體

標(biāo)準(zhǔn)品

血清

形態(tài)病理檢測(cè)

分子病理

超微病理

產(chǎn)品中心

最新產(chǎn)品

相關(guān)文章

小鼠抗SERPINB3單克隆抗體