Name: 小鼠抗SHARPIN單克隆抗體
Brand: 通蔚生物

中文名稱：小鼠抗SHARPIN單克隆抗體

英文名稱： Anti-SHARPIN mouse monoclonal antibody

別名： SHANK associated RH domain interactor; SIPL1

相關(guān)類別：一抗

儲(chǔ) 存： 冷凍（-20℃）

宿主： Mouse

抗原： SHARPIN

反應(yīng)種屬： Human

標(biāo) 記物： Unconjugate

克隆類型： mouse monoclonal

技術(shù)規(guī)格

Background:	Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.
Applications:	WB
Name of antibody:	SHARPIN
Immunogen:	Fusion protein of human SHARPIN
Full name:	SHANK associated RH domain interactor
Synonyms:	SIPL1
SwissProt:	Q9H0F6
WB Predicted band size:	40 KD
WB Positive control:	Hela, Jurkat, 293T cell lysates
WB Recommended dilution:	500-2000

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