購(gòu)物車
幫助
021-54845833/15800441009
中文名稱：ACY1 抗原（重組蛋白）
英文名稱： ACY1 Antigen (Recombinant Protein)
別 名： aminoacylase 1; ACY-1; ACY1D
儲(chǔ) 存： 冷凍（-20℃）
相關(guān)類別： 抗原
概 述：
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Fusion protein corresponding to C terminal 250 amino acids of human ACY1 |
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Full name: |
aminoacylase 1 |
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Synonyms: |
ACY-1; ACY1D |
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Swissprot: |
Q03154 |
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Gene Accession: |
BC000545 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18. |
