Name: ASCC1抗原（重組蛋白）
Brand: 通蔚生物

中文名稱：ASCC1抗原（重組蛋白）

英文名稱： ASCC1 Antigen (Recombinant Protein)

別名： p50; CGI-18; ASC1p50

儲(chǔ) 存： 冷凍（-20℃）

相關(guān)類別： 抗原

概述：

Fusion protein corresponding to C terminal 250 amino acids of human ASCC1

技術(shù)規(guī)格：

Full name:	activating signal cointegrator 1 complex subunit 1
Synonyms:	p50; CGI-18; ASC1p50
Swissprot:	Q8N9N2
Gene Accession:	BC012291
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.

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