Name: PLAU抗原（重組蛋白）
Brand: 通蔚生物

中文名稱： PLAU抗原（重組蛋白）

英文名稱： PLAU Antigen (Recombinant Protein)

別名： ATF; QPD; UPA; URK; u-PA; BDPLT5

儲(chǔ) 存： 冷凍（-20℃）

相關(guān)類別：抗原

概述

Fusion protein corresponding to a region derived from 179-417 amino acids of human PLAU

技術(shù)規(guī)格

Full name:	plasminogen activator, urokinase
Synonyms:	ATF; QPD; UPA; URK; u-PA; BDPLT5
Swissprot:	P00749
Gene Accession:	BC013575
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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