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  • PPM1D 抗原(重組蛋白)

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    • 品牌 : 通蔚生物
    • 目錄號 : TW17576
    • 應用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現貨
    • 商品庫存:90
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中文名稱:PPM1D 抗原(重組蛋白)

英文名稱: PPM1D Antigen (Recombinant Protein)

別      名: protein phosphatase, Mg2+/Mn2+ dependent 1D; WIP1; PP2C-DELTA

儲      存: 冷凍(-20℃)

相關類別: 抗原

概  述:

Fusion protein corresponding to a region derived from 459-605 amino acids of human PPM1D


技術規格:

Full name:

protein phosphatase, Mg2+/Mn2+ dependent 1D

Synonyms:

WIP1; PP2C-DELTA

Swissprot:

O15297

Gene Accession:

BC033893

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.


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