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  • TRAF6 抗原(重組蛋白)

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    • 品牌 : 通蔚生物
    • 目錄號 : TW17816
    • 應用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現貨
    • 商品庫存:90
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中文名稱:TRAF6 抗原(重組蛋白)

英文名稱: TRAF6 Antigen (Recombinant Protein)

別      名: TNF receptor associated factor 6; RNF85; MGC:3310

儲      存: 冷凍(-20℃)

相關類別 抗原

概  述:

Fusion protein corresponding to a region derived from 350-522 amino acids of human TRAF6


技術規格

Full name:

TNF receptor associated factor 6

Synonyms:

RNF85; MGC:3310

Swissprot:

Q9Y4K3

Gene Accession:

BC031052

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain. Two alternatively spliced transcript variants, encoding an identical protein, have been reported.


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