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中文名稱： LRRC19 抗原（重組蛋白）
英文名稱： LRRC19 Antigen (Recombinant Protein)
別 名： leucine rich repeat containing 19
相關(guān)類別： 抗原
概 述
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Fusion protein corresponding to a region derived from 171-370 amino acids of human LRRC19 |
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Full name: |
leucine rich repeat containing 19 |
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Swissprot: |
Q9H756 |
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Gene Accession: |
BC126156 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
LRRC19 is a member of the extracellular leucine-rich repeat superfamily, a family of proteins that are thought to have diverse functions such as cell adhesion, signaling, and innate immunity. LRRC19 is closely related to the Toll-like receptors (TLRs), especially TLR3. LRRC19 does not contain a cytoplasmic Toll/IL-1 receptor (TIR) domain, but can activate NF-kappaB and induce the production of proinflammatory cytokines after stimulation with the TLR3 and other TLR ligands, suggesting that LRRC19 may play a role in the recognition and the response to certain pathogenic microorganisms. LRRC19 has also been suggested to be a potential biomarker for pancreatic tumor sensitivity to the anti-cancer, small molecule Src inhibitor AZD0530. |
