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021-54845833/15800441009
中文名稱： 兔抗RCOR1多克隆抗體
英文名稱： Anti-RCOR1 rabbit polyclonal antibody
別 名： REST corepressor 1; RCOR; COREST
相關(guān)類別： 一抗
抗 原： RCOR1
儲 存： 冷凍（-20℃）
宿 主： Rabbit
反應(yīng)種屬： Human, Mouse
標(biāo) 記 物： Unconjugate
克隆類型： rabbit polyclonal
Background:
Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation.
Applications:
ELISA, WB, IHC
Name of antibody:
RCOR1
Immunogen:
Synthetic peptide of human RCOR1
Full name:
REST corepressor 1
Synonyms:
RCOR; COREST
SwissProt:
Q9UKL0
ELISA Recommended dilution:
5000-10000
IHC positive control:
Human ovarian cancer and human lung cancer
IHC Recommend dilution:
20-100
WB Predicted band size:
53 kDa
WB Positive control:
A431,231 and PC-3 cell lysates
WB Recommended dilution:
200-1000
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