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  • TPSB2抗原(重組蛋白)

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    • 品牌 : 通蔚生物
    • 目錄號 : TW19989
    • 應用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現貨
    • 商品庫存:60
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中文名稱: TPSB2抗原(重組蛋白)

英文名稱: TPSB2 Antigen (Recombinant Protein)

別     名:  TPS2; tryptaseB; tryptaseC

儲     存:  冷凍(-20℃)

相關類別: 抗原

概      述

Full length fusion protein

技術規格

Full name:

tryptase beta 2 (gene/pseudogene)

Synonyms:

TPS2; tryptaseB; tryptaseC

Swissprot:

P20231

Gene Accession:

BC029356

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, beta II and beta III. Beta tryptases appear to be the main isoenzymes expressed in mast cells, whereas in basophils, alpha-tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.



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