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021-54845833/15800441009
中文名稱： 兔抗RELB (Phospho-Ser573) 多克隆抗體
英文名稱： Anti-RELB (Phospho-Ser573) rabbit polyclonal antibody
別 名： IREL; I-REL; REL-B
相關(guān)類別： 一抗
儲(chǔ) 存： 冷凍（-20℃） 避光
宿 主： Rabbit
抗 原： RELB (Phospho-Ser573)
反應(yīng)種屬： Human Mouse Rat
標(biāo) 記 物： Unconjugate
克隆類型： rabbit polyclonal
Background:
NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators.
Applications:
WB, IHC
Name of antibody:
RELB (Phospho-Ser573)
Immunogen:
Synthetic peptide of human RELB (Phospho-Ser573)
Full name:
v-rel reticuloendotheliosis viral oncogene homolog B (Phospho-Ser573)
Synonyms：
IREL; I-REL; REL-B
SwissProt:
Q01201
IHC positive control:
Human breast carcinoma
IHC Recommend dilution:
50-100
WB Recommended dilution:
500-1000
WB Positive control:
HUVEC cells untreated or treated with TNF
WB Predicted band size:
70 kDa
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