中文名稱：兔抗Fadd(Phospho-Ser191) 多克隆抗體

英文名稱： Anti-Fadd(Phospho-Ser191) rabbit polyclonal antibody

別名： GIG3; MORT1

相關(guān)類別： 一抗

儲存： 冷凍（-20℃）避光

宿主： Rabbit

抗原： Fadd(Phospho-Ser191)

反應(yīng)種屬： Human Mouse

標記物： Unconjugate

克隆類型： Unconjugate

技術(shù)規(guī)格

Background:

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]

Applications:

WB, IHC

Name of antibody:

Fadd(Phospho-Ser191)

Immunogen:

Peptide sequence around phosphorylation site of Serine191(R-S-G(p)-A-M) derived from Human FADD.

Full name:

Fas (TNFRSF6)-associated via death domain

Synonyms：

GIG3; MORT1

SwissProt:

Q13158

IHC positive control:

Human breast carcinoma tissue

IHC Recommend dilution:

50-100

WB Predicted band size:

23 kDa

WB Positive control:

Jurkat cells lysates treated with PMA

WB Recommended dilution:

500-1000

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細胞專用培養(yǎng)基

菌株

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病理染色液

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兔抗Fadd(Phospho-Ser191) 多克隆抗體

Background:	The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]
Applications:	WB, IHC
Name of antibody:	Fadd(Phospho-Ser191)
Immunogen:	Peptide sequence around phosphorylation site of Serine191(R-S-G(p)-A-M) derived from Human FADD.
Full name:	Fas (TNFRSF6)-associated via death domain
Synonyms：	GIG3; MORT1
SwissProt:	Q13158
IHC positive control:	Human breast carcinoma tissue
IHC Recommend dilution:	50-100
WB Predicted band size:	23 kDa
WB Positive control:	Jurkat cells lysates treated with PMA
WB Recommended dilution:	500-1000