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021-54845833/15800441009
中文名稱： 兔抗NARF多克隆抗體
英文名稱： Anti-NARF rabbit polyclonal antibody
別 名： nuclear prelamin A recognition factor; IOP2
相關(guān)類別： 一抗
儲 存： 冷凍（-20℃）
宿 主： Rabbit
抗 原： NARF
反應種屬： Human, Mouse, Rat
標 記 物： Unconjugate
克隆類型： rabbit polyclonal
技術(shù)規(guī)格
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Background: |
Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
NARF |
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Immunogen: |
Fusion protein of human NARF |
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Full name: |
nuclear prelamin A recognition factor |
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Synonyms: |
IOP2 |
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SwissProt: |
Q9UHQ1 |
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ELISA Recommended dilution: |
5000-10000 |
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IHC positive control: |
Human ovarian cancer |
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IHC Recommend dilution: |
50-300 |
