購物車
幫助
021-54845833/15800441009
中文名稱： 兔抗NCF1多克隆抗體
英文名稱： Anti-NCF1 rabbit polyclonal antibody
別 名： NCF1; FLJ79451; NCF1A; NOXO2; SH3PXD1A; p47phox
相關(guān)類別： 一抗
儲 存： 冷凍（-20℃） 避光
宿 主： Rabbit
抗 原： NCF1
反應種屬： Human, Mouse, Rat
標 記 物： Unconjugate
克隆類型： rabbit polyclonal
技術(shù)規(guī)格
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Background: |
The phagocytic NADPH oxidase is a multiprotein enzyme that catalyzes the reduction of oxygen to superoxide in response to pathogenic invasion. The NADPH oxidase consists of 6 subunits, including the membrane-bound p91 phox and p22 phox heterodimers (also known as cytochrome b558), the cytosolic complex of p40phox, p47phox and p67phox, and the small GTPase Rac2. Activation of NADPH oxidase is initiated by cytosolic complex phosphorylation, which induces a conformational change that leads to the translocation of the cytosolic complex to the membrane and formation of an active enzyme with cytochrome b558. Defects in p47phox, often resulting from recombination between p47phox and a nearby homologous pseudogene, cause chronic granulomatous disease. Elevated oxidative stress due to increased myocardial NADPH oxidase activity may be a contributing factor in heart failure. |
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Applications: |
WB |
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Name of antibody: |
NCF1 |
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Immunogen: |
Fusion protein of human NCF1 |
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Full name: |
neutrophil cytosolic factor 1 |
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Synonyms： |
NCF1; FLJ79451; NCF1A; NOXO2; SH3PXD1A; p47phox |
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SwissProt: |
P14598 |
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WB Predicted band size: |
45 kDa |
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WB Positive control: |
T470 cells |
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WB Recommended dilution: |
500-2000 |
