購(gòu)物車
幫助
021-54845833/15800441009
中文名稱： 兔抗PHAX多克隆抗體
英文名稱： Anti-PHAX rabbit polyclonal antibody
別 名： RNUXA
相關(guān)類別： 一抗
儲(chǔ) 存： 冷凍（-20℃） 避光
宿 主： Rabbit
抗 原： PHAX
反應(yīng)種屬： Human
標(biāo) 記 物： Unconjugate
克隆類型： rabbit polyclonal
技術(shù)規(guī)格
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WB Recommended dilution: |
500-3000 |
|
WB Positive control: |
HT-29 cells lysate |
|
WB Predicted band size: |
44 kDa |
|
SwissProt: |
Q9H814 |
|
Synonyms： |
RNUXA |
|
Full name: |
phosphorylated adaptor for RNA export |
|
Immunogen: |
Synthesized peptide derived from internal of human RNUXA. |
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Name of antibody: |
PHAX |
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Applications: |
WB |
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Background: |
A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner By similarity. Plays also a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA. |
