購(gòu)物車(chē)
幫助
021-54845833/15800441009
中文名稱(chēng)： 兔抗PLCE1多克隆抗體
英文名稱(chēng)： Anti-PLCE1 rabbit polyclonal antibody
別 名： phospholipase C epsilon 1; PLCE; PPLC; NPHS3
相關(guān)類(lèi)別： 一抗
儲(chǔ) 存： 冷凍（-20℃）
抗 原： PLCE1
宿 主： Rabbit
反應(yīng)種屬： Human
標(biāo) 記 物： Unconjugate
克隆類(lèi)型： rabbit polyclonal
技術(shù)規(guī)格
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Background: |
This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome; characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
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Applications: |
WB |
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Name of antibody: |
PLCE1 |
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Immunogen: |
Synthetic peptide of human PLCE1 |
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Full name: |
phospholipase C epsilon 1 |
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Synonyms: |
PLCE; PPLC; NPHS3 |
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SwissProt: |
Q9P212 |
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WB Predicted band size: |
259 kDa |
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WB Positive control: |
HEK293 cells |
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WB Recommended dilution: |
500-1000 |
