購物車
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021-54845833/15800441009
中文名稱： 兔抗PSAP多克隆抗體
英文名稱： Anti-PSAP rabbit polyclonal antibody
別 名： FLJ00245; GLBA; MGC110993; SAP1
相關(guān)類別： 一抗
儲 存： 冷凍（-20℃） 避光
宿 主： Rabbit
抗 原： PSAP
反應(yīng)種屬： Human, Mouse, Rat
標(biāo) 記 物： Unconjugate
克隆類型： rabbit polyclonal
技術(shù)規(guī)格
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Background: |
The PSAP gene encodes prosaposin, a precursor of four small nonenzymatic glycoproteins termed 'sphingolipid activator proteins' (SAPs) that assist in the lysosomal hydrolysis of sphingolipids. After proteolytic processing of the presaposin protein, these 4 released polypeptides are functional activators. Saposin A is encoded by residues 60 to 143 of PSAP, saposin B by 195 to 275, saposin C by 311 to 390, and saposin D by 405 to 487. They are four 12-14 kDa heatstable glycoproteins. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. Saposins A-D are required for the hydrolysis of certain sphingolipids by specific lysosomal hydrolases. Defects in PSAP are the cause of Gaucher disease, Tay-Sachs disease, and metachromatic leukodystrophy. This PSAP antibody (10801-1-AP) is expected to recognize both saposin A and B. |
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Applications: |
WB |
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Name of antibody: |
PSAP |
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Immunogen: |
Fusion protein of human PSAP |
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Full name: |
prosaposin |
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Synonyms： |
FLJ00245; GLBA; MGC110993; SAP1 |
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SwissProt: |
P07602 |
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WB Predicted band size: |
58 kDa |
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WB Positive control: |
HEK-293 cells |
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WB Recommended dilution: |
500-2000 |
