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中文名稱： 兔抗TRIM28多克隆抗體
英文名稱： Anti-TRIM28 rabbit polyclonal antibody
別 名： KAP1; TF1B; RNF96; TIF1B
相關(guān)類別： 一抗
儲 存： 冷凍（-20℃） 避光
宿 主： Rabbit
抗 原： TRIM28
反應(yīng)種屬： Human, Mouse, Rat
標(biāo) 記 物： Unconjugate
克隆類型： rabbit polyclonal
技術(shù)規(guī)格
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Background: |
Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. |
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Applications: |
WB |
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Name of antibody: |
TRIM28 |
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Immunogen: |
Synthetic peptide of human TRIM28 |
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Full name: |
tripartite motif containing 28 |
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Synonyms： |
KAP1; TF1B; RNF96; TIF1B |
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SwissProt: |
Q13263 |
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WB Predicted band size: |
89 kDa |
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WB Positive control: |
Jurkat, T98G, COS7 and Hela cells |
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WB Recommended dilution: |
500-1000 |
