中文名稱：兔抗TP53 (Phospho-Ser46)多克隆抗體

英文名稱： Anti-TP53 (Phospho-Ser46) rabbit polyclonal antibody

別名： P53; BCC7; LFS1; TRP53

相關(guān)類別：一抗

儲(chǔ) 存： 冷凍（-20℃）避光

宿主： Rabbit

抗原： TP53 (Phospho-Ser46)

反應(yīng)種屬： Human

標(biāo) 記物： Unconjugate

克隆類型： rabbit polyclonal

技術(shù)規(guī)格

Background:

p53 is a nuclear protein which plays an essential role in the regulation of cell cycle specifically in the transition from G0 to G1. It is found in very low levels in normal cells however in a variety of transformed cell lines in high amounts and believed to contribute to transformation and malignancy. The open reading frame of p53 is 393 amino acids long, with the central region (consisting of amino acids from about 100 to 300) containing the DNA-binding domain. This proteolysis-resistant core is flanked by a C-terminal end mediating oligomerization and an N-terminal end containing a strong transcription activation signal. p53 binds as a tetramer to a PBS (p53-Binding Site) and activates the expression of downstream genes that inhibit growth and/or invasion. p53 binds as a tetramer to a p53-binding site (PBS) and to activate the expression of adjacent genes that inhibit growth and/or invasion. Deletion of one or both p53 alleles reduces the expression of tetramers, resulting in decreased expression of the growth inhibitory genes

Applications:

WB, IF

Name of antibody:

TP53 (Phospho-Ser46)

Immunogen:

Synthetic peptide of human TP53 (Phospho-Ser46)

Full name:

tumor protein p53 (Phospho-Ser46)

Synonyms：

P53; BCC7; LFS1; TRP53

SwissProt:

P04637

WB Predicted band size:

44 kDa

WB Positive control:

MCF cells untreated or treated with Anisomycin

WB Recommended dilution:

500-1000

IF Positive control:

Hela cells

IF Recommended dilution

100-200

展開(kāi)全部

兔抗TP53 (Phospho-Ser46)多克隆抗體說(shuō)明書
下載

久久综合九九-久久综合九九亚洲一区-久久综合九色-久久综合九色欧美综合狠狠-久久综合九色婷婷97-久久综合九色综合8888

021-54845833/15800441009

ELISA試劑盒

PCR試劑盒

生化試劑盒

細(xì)胞系

細(xì)胞庫(kù)

基礎(chǔ)培養(yǎng)基

完全培養(yǎng)基

原代細(xì)胞

細(xì)胞專用培養(yǎng)基

菌株

生化試劑

病理染色液

科研抗體

標(biāo)準(zhǔn)品

血清

形態(tài)病理檢測(cè)

分子病理

超微病理

產(chǎn)品中心

最新產(chǎn)品

相關(guān)文章

兔抗TP53 (Phospho-Ser46)多克隆抗體

Background:	p53 is a nuclear protein which plays an essential role in the regulation of cell cycle specifically in the transition from G0 to G1. It is found in very low levels in normal cells however in a variety of transformed cell lines in high amounts and believed to contribute to transformation and malignancy. The open reading frame of p53 is 393 amino acids long, with the central region (consisting of amino acids from about 100 to 300) containing the DNA-binding domain. This proteolysis-resistant core is flanked by a C-terminal end mediating oligomerization and an N-terminal end containing a strong transcription activation signal. p53 binds as a tetramer to a PBS (p53-Binding Site) and activates the expression of downstream genes that inhibit growth and/or invasion. p53 binds as a tetramer to a p53-binding site (PBS) and to activate the expression of adjacent genes that inhibit growth and/or invasion. Deletion of one or both p53 alleles reduces the expression of tetramers, resulting in decreased expression of the growth inhibitory genes
Applications:	WB, IF
Name of antibody:	TP53 (Phospho-Ser46)
Immunogen:	Synthetic peptide of human TP53 (Phospho-Ser46)
Full name:	tumor protein p53 (Phospho-Ser46)
Synonyms：	P53; BCC7; LFS1; TRP53
SwissProt:	P04637
WB Predicted band size:	44 kDa
WB Positive control:	MCF cells untreated or treated with Anisomycin
WB Recommended dilution:	500-1000
IF Positive control:	Hela cells
IF Recommended dilution	100-200