購(gòu)物車
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021-54845833/15800441009
中文名稱：兔抗CASP12多克隆抗體
英文名稱： Anti-CASP12 rabbit polyclonal antibody
別 名： CASP-12, CASP12P1
相關(guān)類別： 一抗
抗 原： CASP12
儲(chǔ) 存： 冷凍（-20℃）
宿 主： Rabbit
反應(yīng)種屬： Human, Mouse
標(biāo) 記 物： Unconjugate
克隆類型： rabbit polyclonal
技術(shù)規(guī)格
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Background: |
Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. |
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Applications: |
ELISA, WB, IHC |
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Name of antibody: |
CASP12 |
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Immunogen: |
Synthetic peptide of human CASP12 |
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Full name: |
caspase 12 (gene/pseudogene) |
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Synonyms: |
CASP-12; CASP12P1 |
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SwissProt: |
Q6UXS9 |
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ELISA Recommended dilution: |
5000-10000 |
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IHC positive control: |
Human liver cancer |
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IHC Recommend dilution: |
30-150 |
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WB Predicted band size: |
39 kDa |
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WB Positive control: |
NIH/3T3 cell lysate |
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WB Recommended dilution: |
500-2000 |
