Name: COL4A1抗原
Brand: 通蔚生物

中文名稱：COL4A1抗原

英文名稱：COL4A1 Antigen

相關(guān)類別：抗原

儲存： 冷凍（-20℃）

概述

Synthetic peptide corresponding to a region derived from 1648-1662 amino acids of human collagen type IV alpha 1 chain

技術(shù)規(guī)格

Full name	collagen type IV alpha 1 chain
Synonyms	BSVD; RATOR
Swissprot	P02462
Gene Accession	NP_001836
Background	This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants.

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